Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer’s Disease
vaxxter,com
Abstract
In this paper, I have summarized the experimental and largely clinical evidence that implicates aluminum as a primary etiological factor in Alzheimer’s disease. The unequivocal neurotoxicity of aluminum must mean that when brain burdens of aluminum exceed toxic thresholds that it is inevitable that aluminum contributes toward disease. Aluminum acts as a catalyst for an earlier onset of Alzheimer’s disease in individuals with or without concomitant predispositions, genetic or otherwise. Alzheimer’s disease is not an inevitable consequence of aging in the absence of a brain burden of aluminum.
EVIDENCE NOW POINTS TO ALUMINUM AS A CONTRIBUTORY FACTOR IN ALL FORMS OF ALZHEIMER’S DISEASE
Aluminum is unquestionably neurotoxic [1] and it is accepted as the cause of encephalopathies in, for example, individuals undergoing renal dialysis [2] and similarly in individuals who have received aluminum-based prostheses [3]. There are myriad ways by which aluminum can exert toxicity; its Al3 + (aq) ion is highly biologically reactive, but to do so and thereby bring about change in a biochemical system, the aluminum content of any compartment, such as a tissue, must achieve a toxic threshold or burden [4]. However, aluminum-induced encephalopathies are not Alzheimer’s disease, though they may share some similar neuropathological hallmarks [5]; they are acute conditions whereas Alzheimer’s disease might now be considered as an acute response to chronic intoxication byaluminum [1].
WE DO NOT KNOW WHAT CAUSES ALZHEIMER’S DISEASE
While the causes of Alzheimer’s disease remain unknown, we do know that the neuropathology of Alzheimer’s disease, if not the disease per se, and specifically in relation to the deposition of amyloid-? and tau can be reproduced in transgenic animal models [6]. We also know that the addition of aluminum to feed or water exacerbates the many symptoms of Alzheimer’s disease in these animal models [7, 8].
WHAT ARE THE PERTINENT RISK FACTORS FOR ALZHEIMER’S DISEASE?
In the majority of individuals, aging is perhaps the single most important risk factor for the